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How is IMFINZI given?

IMFINZI and chemotherapy* are intravenous (IV) infusions

Depending on your doctor’s office, you may receive treatment in their office or at a local infusion center. For the first part of the treatment period, called initial treatment, IMFINZI is given with chemotherapy.* Then IMFINZI is given alone for the second part of treatment, called maintenance. If your doctor prescribes IMFINZI in combination with chemotherapy* to treat your advanced or recurrent dMMR endometrial cancer, you will be given this combination for 6 cycles of your treatment before receiving IMFINZI alone. For these cycles during which you receive IMFINZI and chemotherapy*, you will receive IMFINZI first followed by chemotherapy* on the same day.

*Carboplatin and paclitaxel.

Initial treatment

18 weeks or 6 cycles
(each cycle is 3 weeks long)

IMFINZI infusion

IMFINZI
every 3 weeks

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Chemotherapy* infusion

Chemotherapy*
every 3 weeks

Maintenance

Until disease progresses or you and your
doctor decide to stop treatment

IMFINZI infusion

IMFINZI
every 4 weeks

How long are infusions?

IMFINZI infusions last 60 minutes. There may also be some extra time before or after the infusion for your doctor to run some tests. If your doctor prescribes IMFINZI in combination with chemotherapy* to treat your advanced or recurrent dMMR endometrial cancer, you will be given this combination for 6 cycles of your treatment before receiving IMFINZI alone. For these cycles during which you receive IMFINZI and chemotherapy*, you will receive IMFINZI first followed by chemotherapy* on the same day. The length of these treatments may be different.

How many cycles of treatment will I need?

The number of treatments will be determined by your doctor, depending on the condition of your cancer. You will stop receiving IMFINZI if your cancer progresses or if side effects become intolerable.

Signs and symptoms of infusion reactions to look out for

Infusion reactions can sometimes be severe or life-threatening. Call or see your healthcare provider right away if you develop symptoms of the following problems or if these symptoms worsen. Signs and symptoms include:

  • Chills or shaking
  • Itching or rash
  • Flushing
  • Shortness of breath or wheezing
  • Dizziness
  • Feeling like passing out
  • Fever
  • Back or neck pain

Call or see your doctor right away if you develop any new or worsening signs or symptoms, including:

FPO

  • Lung problems: cough, shortness of breath, and chest pain

  • Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; and severe stomach-area (abdomen) pain or tenderness

  • Liver problems: yellowing of your skin or the whites of your eyes, severe nausea or vomiting, pain on the right side of your stomach area (abdomen), dark urine (tea colored), and bleeding or bruising more easily than normal

  • Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; and changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness

  • Kidney problems: decrease in your amount of urine, blood in your urine, swelling of your ankles, and loss of appetite

  • Skin problems: rash; itching; skin blistering or peeling; painful sores or ulcers in mouth or nose, throat, or genital area; fever or flu-like symptoms; and swollen lymph nodes

  • Pancreas problems: pain in your upper stomach area (abdomen), severe nausea or vomiting, and loss of appetite

  • Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with IMFINZI. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include: Chest pain, irregular heartbeats, shortness of breath or swelling of ankles; confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling, numbness or weakness of the arms or legs; double vision, blurry vision, sensitivity to light, eye pain, changes in eye sight; persistent or severe muscle pain or weakness, muscle cramps, joint pain, joint stiffness or swelling; and low red blood cells and bruising

  • Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include: chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feel like passing out, fever, and back or neck pain

  • Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with IMFINZI. Your healthcare provider will monitor you for these complications

FPO

The most common side effects of IMFINZI include:

  • Feeling tired

  • Nausea

  • Constipation

  • Decreased apetite

  • Stomach (abdominal) pain

  • Rash

  • Fever

Tell your doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of IMFINZI. Please see additional Important Safety Information throughout and Full
Prescribing Information for IMFINZI.

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Tracking side effects

Once you start treatment, it can be helpful to take note of any side effects you're experiencing. Being specific about your symptoms may help your doctor make recommendations on how to manage them.
While tracking side effects, consider asking yourself the following questions:

  • What symptoms are you experiencing?
  • Are these symptoms mild, moderate, or severe?
  • When do they occur?
  • How often do they occur?
  • How long do they typically last?
  • What’s your level of discomfort?
  • Do you feel better after resting or taking medicine?
  • How are your symptoms affecting your daily life?
  • Is your doctor aware of your symptoms?

*Carboplatin and paclitaxel.

Learn how to prepare for infusions
See tips

Important Safety Information

What is the most important information I should know about IMFINZI?

IMFINZI is a medicine that may treat certain cancers by working with your immune system. IMFINZI can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.

What is IMFINZI?

IMFINZI is a prescription medicine that is used in combination with the chemotherapy medicines carboplatin and paclitaxel followed by IMFINZI alone to treat a type of uterine cancer called endometrial cancer that has spread (advanced) or has come back (recurred) and a laboratory test shows that your tumor is mismatch repair deficient (dMMR).

It is not known if IMFINZI is safe and effective in children.

Call or see your healthcare provider right away if you develop any new or worsening signs or symptoms, including:

  • Lung problems: cough, shortness of breath, and chest pain

  • Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; and severe stomach-area (abdomen) pain or tenderness

  • Liver problems: yellowing of your skin or the whites of your eyes, severe nausea or vomiting, pain on the right side of your stomach area (abdomen), dark urine (tea colored), and bleeding or bruising more easily than normal

  • Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; and changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness

  • Kidney problems: decrease in your amount of urine, blood in your urine, swelling of your ankles, and loss of appetite

  • Skin problems: rash; itching; skin blistering or peeling; painful sores or ulcers in mouth or nose, throat, or genital area; fever or flu-like symptoms; and swollen lymph nodes

  • Pancreas problems: pain in your upper stomach area (abdomen), severe nausea or vomiting, and loss of appetite

  • Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with IMFINZI. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include: Chest pain, irregular heartbeats, shortness of breath or swelling of ankles; confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling, numbness or weakness of the arms or legs; double vision, blurry vision, sensitivity to light, eye pain, changes in eye sight; persistent or severe muscle pain or weakness, muscle cramps, joint pain, joint stiffness or swelling; and low red blood cells and bruising

  • Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include: chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feel like passing out, fever, and back or neck pain

  • Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with IMFINZI. Your healthcare provider will monitor you for these complications

Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with IMFINZI. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with IMFINZI if you have severe side effects.

Before you receive IMFINZI, tell your healthcare provider about all of your medical conditions, including if you:

  • have immune system problems such as Crohn's disease, ulcerative colitis, or lupus
  • have received an organ transplant
  • have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
  • have received radiation treatment to your chest area
  • have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome
  • are pregnant or plan to become pregnant. IMFINZI can harm your unborn baby

    • Females who are able to become pregnant:

    • Your healthcare provider will give you a pregnancy test before you start treatment with IMFINZI.
    • You should use an effective method of birth control during your treatment and for 3 months after the last dose of IMFINZI. Talk to your healthcare provider about birth control methods that you can use during this time.
    • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with IMFINZI.
  • are breastfeeding or plan to breastfeed. It is not known if IMFINZI passes into your breast milk. Do not breastfeed during treatment and for 3 months after the last dose of IMFINZI.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of IMFINZI?

IMFINZI can cause serious side effects (see above):

The most common side effects of IMFINZI when used with platinum-containing chemotherapy in adults with endometrial cancer include inflammation of the nerves causing numbness, weakness, tingling or burning pain of the arms and legs, muscle or bone pain, nausea, hair loss, feeling tired, stomach (abdominal) pain, constipation, rash, decreased level of magnesium in the blood, increased liver function tests, diarrhea, vomiting, cough, decreased level of potassium in the blood, shortness of breath, headache, increased level of alkaline phosphate in the blood, and decreased appetite.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of IMFINZI. Ask your healthcare provider or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects related to AstraZeneca products.Report side effects related to AstraZeneca products If you prefer to report these to the FDA, either visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

Call your doctor for medical advice about side effects. You may report side effects related to AstraZeneca products.Report side effects related to AstraZeneca products If you prefer to report these to the FDA, either visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

What is IMFINZI?

IMFINZI is a prescription medicine that is used in combination with the chemotherapy medicines carboplatin and paclitaxel followed by IMFINZI alone to treat a type of uterine cancer called endometrial cancer that has spread (advanced) or has come back (recurred) and a laboratory test shows that your tumor is mismatch repair deficient (dMMR).

It is not known if IMFINZI is safe and effective in children.

Please see Full Prescribing Information including Medication Guide for IMFINZI.

What is IMFINZI?

Important Safety Information

What is the most important information I should know about IMFINZI?

IMFINZI is a medicine that may treat certain cancers by working with your immune system. IMFINZI can cause your immune system to attack normal organs and tissues in any area of your body and can affect...

IMFINZI is a medicine that may treat...

Read full Important Safety Information

Important Safety Information

What is IMFINZI?

Minimize Expand

IMFINZI is a prescription medicine that is used in combination with the chemotherapy medicines carboplatin and paclitaxel followed by IMFINZI alone to treat a type of uterine cancer called endometrial cancer that has...

What is the most important information I should know about IMFINZI?

IMFINZI is a medicine that may treat certain cancers by work...

IMFINZI is a medicine that may treat certain cancers by working with your immune system. IMFINZI can cause your immune system to...

Read full Important Safety Information