How IMFINZI is given

After decades with few advancements in treatment, IMFINZI is the first FDA-approved immunotherapy for limited-stage small cell lung cancer (LS-SCLC) following cCRT (platinum-based chemotherapy and radiation therapy given together).

Take me to:

Take me to:

Taking IMFINZI
Preparing for infusions
Talking to your doctor

What can I expect from treatment with IMFINZI for LS-SCLC?

IMFINZI is an infusion given every 3 weeks after completing chemoradiation therapy

  • To treat limited-stage SCLC, first you’ll:

    Treatment of Limited-Stage SCLC Chemoradiation Therapy

    complete up to 4 cycles of platinum-based chemotherapy and radiation therapy given together. This is known as chemoradiation therapy (cCRT)

  • If the cancer does not progress following cCRT, then you'll:

    IMFINZI Treatment Following cCRT

    receive treatment with IMFINZI every 4 weeks for up to 2 years. Your doctor will determine how often and how long you will receive IMFINZI.

    You will stop receiving IMFINZI if your disease progresses or if your side effects are too difficult to manage.

IMFINZI is given:

  • as an intravenous infusion (usually over 60 minutes)
  • at your doctor’s office or an infusion center

Ask your doctor how long you should stay on IMFINZI. Every person is different. Your doctor will decide how long you will receive IMFINZI and how many treatments you need. He or she will monitor you regularly for possible side effects, and to see if IMFINZI is working to keep your cancer from growing or spreading.

IMFINZI is expanding treatment options for LS-SCLC

IMFINZI is one of few treatment advances for LS-SCLC in 3 decades. Talk to your doctor about how a new treatment option may help treat LS-SCLC after cCRT.


See the clinical trial results

Preparing for your infusion

How do I prepare for my treatment?

During treatment, your comfort matters. A little planning can go a long way to help improve your treatment experience. Here are a few suggestions to help get you ready for treatment day:

Before Treatment Show up Early

Show up early so you don’t feel rushed

Before Treatment Eat a Small Meal

Eat a small meal

Before Treatment Drink Plenty of Water

Drink plenty of water to stay hydrated

Before Treatment Dress in Loose-fitting Clothes

Dress comfortably in loose-fitting clothes

Before Treatment Write Down Any Questions for the Healthcare Team

Write down any questions you may have for your care team

Here are some things to bring that may be useful on treatment days:

During Treatment get Identification or Insurance Card

Identification/
insurance card

During Treatment Get List of Medications You are Taking

List of medications you are taking

During Treatment Get Snacks if You Get Hungry

Snacks in case you get hungry

During Treatment Get Water Bottle to Help Stay Hydrated

Water bottle to help you stay hydrated

During Treatment Get Lotions and Hard Candy to Soothe Dry Skin and Lips

Lip balm, lotion, and hard candy to soothe dry skin and lips

During Treatment Get Sweater or Blanket in Case You Get Cold

Sweater or blanket in case you get cold

During Treatment Get Books, Phones or Charging Devices for Entertainment Purpose

Things to keep you entertained, like reading materials, mobile devices (phone, laptop, tablet), and a charger for your devices

Be sure to notify your doctor if you experience any infusion reactions

After Treatment Schedule Your Next Appointment Before Leaving the Treatment Center

Remember to schedule your next appointment before leaving the treatment center

After Treatment Take Rest for the Day

If possible, take it easy for the rest of the day

After Treatment Contact Healthcare Team if you Develop Any Signs or Symptoms

Contact your healthcare team right away if you develop any new or worsening signs or symptoms

After Treatment Use a Journal to let your Doctor know if you Experience Any Infusion Reactions

Helpful tip: Keep a journal to write down how you are feeling and any questions you may have for your doctor.

How should I talk to my doctor about limited-stage small cell lung cancer?

Having an open and honest conversation about SCLC is key. If you or someone you know has LS-SCLC, and is ready to take the next step, read through the questions below to help prepare for your appointment.

Expand all

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About LS-SCLC

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  • What are the most important things I should know about LS-SCLC?
  • What are the key differences between LS-SCLC and ES-SCLC?
  • How will LS-SCLC affect my day-to-day health?
  • What can I do to reduce the risk of LS-SCLC growing or spreading?
  • Are there any activities I shouldn’t do?

Treating your LS-SCLC

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  • IMFINZI is an immunotherapy. What is that?
  • Why do I need to receive cCRT before taking IMFINZI?
  • What are the side effects of IMFINZI?
  • How will my progress be monitored during treatment with IMFINZI?
  • How is IMFINZI given?

Taking care of yourself

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  • Should I see a nutritionist?
  • Aside from taking medication, what else can I do to keep my lungs as healthy as possible?


Learn more about the treatment journey with IMFINZI

Download the Patient Guide Icon

Important Safety Information

What is the most important information I should know about IMFINZI® (durvalumab)?

IMFINZI is a medicine that may treat certain cancers by working with your immune system. IMFINZI can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.

What is IMFINZI?

IMFINZI is a prescription medicine used to treat adults with a type of lung cancer called SCLC.

  • IMFINZI may be used alone when your LS-SCLC cannot be removed by surgery and has responded or stabilized after initial treatment with chemotherapy that contains platinum, given at the same time as radiation therapy.
  • IMFINZI may be used with the chemotherapy medicines etoposide and either carboplatin or cisplatin as your first treatment when your SCLC has spread within your lungs or to other parts of the body (extensive-stage small cell lung cancer, or ES-SCLC).

It is not known if IMFINZI is safe and effective in children.

Call or see your healthcare provider right away if you develop any new or worsening signs or symptoms, including:

  • SCLC Lung Problems Icon

    Lung problems: cough, shortness of breath, and chest pain

  • SCLC Intestinal Problems Icon

    Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; and severe stomach-area (abdomen) pain or tenderness

  • SCLC Liver Problems Icon

    Liver problems: yellowing of your skin or the whites of your eyes, severe nausea or vomiting, pain on the right side of your stomach area (abdomen), dark urine (tea colored), and bleeding or bruising more easily than normal

  • SCLC Hormone Gland Problems Icon

    Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; and changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness

  • SCLC Kidney Problems Icon

    Kidney problems: decrease in your amount of urine, blood in your urine, swelling of your ankles, and loss of appetite

  • SCLC Skin Problems Icon

    Skin problems: rash; itching; skin blistering or peeling; painful sores or ulcers in mouth or nose, throat, or genital area; fever or flu-like symptoms; and swollen lymph nodes

  • SCLC Pancreas Problems Icon

    Pancreas problems: pain in your upper stomach area (abdomen), severe nausea or vomiting, and loss of appetite

  • SCLC Other Organ Problems Icon

    Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with IMFINZI. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include: Chest pain, irregular heartbeats, shortness of breath or swelling of ankles; confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems; tingling, numbness or weakness of the arms or legs; double vision, blurry vision, sensitivity to light, eye pain, changes in eye sight; persistent or severe muscle pain or weakness, muscle cramps, joint pain, joint stiffness or swelling; and low red blood cells and bruising

  • SCLC Severe Infusion Reactions Icon

    Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include: chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feel like passing out, fever, and back or neck pain

  • SCLC Transplant Complications Icon

    Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with IMFINZI. Your healthcare provider will monitor you for these complications

Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with IMFINZI. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with IMFINZI if you have severe side effects

Before you receive IMFINZI, tell your healthcare provider about all of your medical conditions, including if you:

  • have immune system problems such as Crohn's disease, ulcerative colitis, or lupus
  • have received an organ transplant
  • have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
  • have received radiation treatment to your chest area
  • have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome
  • are pregnant or plan to become pregnant. IMFINZI can harm your unborn baby

    • Females who are able to become pregnant:

    • Your healthcare provider will give you a pregnancy test before you start treatment with IMFINZI.
    • You should use an effective method of birth control during your treatment and for 3 months after the last dose of IMFINZI. Talk to your healthcare provider about birth control methods that you can use during this time.
    • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with IMFINZI.
  • are breastfeeding or plan to breastfeed. It is not known if IMFINZI passes into your breast milk. Do not breastfeed during treatment and for 3 months after the last dose of IMFINZI.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of IMFINZI?

IMFINZI can cause serious side effects (see above):

The most common side effects of IMFINZI when used alone in adults with limited-stage small cell lung cancer (LS-SCLC) include inflammation in the lungs and feeling tired or weak.

The most common side effects of IMFINZI when used with etoposide and either carboplatin or cisplatin in adults with extensive-stage small cell lung cancer (ES-SCLC) include nausea, hair loss, and feeling tired or weak.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of IMFINZI. Ask your healthcare provider or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects related to AstraZeneca products.Report side effects related to AstraZeneca products If you prefer to report these to the FDA, either visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

Call your doctor for medical advice about side effects. You may report side effects related to AstraZeneca products.Report side effects related to AstraZeneca products If you prefer to report these to the FDA, either visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

What is IMFINZI?

IMFINZI is a prescription medicine used to treat adults with a type of lung cancer called small cell lung cancer (SCLC).

  • IMFINZI may be used alone when your LS-SCLC cannot be removed by surgery and has responded or stabilized after initial treatment with chemotherapy that contains platinum, given at the same time as radiation therapy.
  • IMFINZI may be used with the chemotherapy medicines etoposide and either carboplatin or cisplatin as your first treatment when your SCLC has spread within your lungs or to other parts of the body (extensive-stage small cell lung cancer, or ES-SCLC).

It is not known if IMFINZI is safe and effective in children.

Please see Full Prescribing Information including Medication Guide for IMFINZI.

What is IMFINZI?

Important Safety Information

What is the most important information I should know about IMFINZI® (durvalumab)?

IMFINZI is a medicine that may treat certain cancers by working with your immune system. IMFINZI can cause your immune system to attack normal organs and tissues in...

IMFINZI is a medicine that may treat...

Read full Important Safety Information

Important Safety Information

What is IMFINZI?

Minimize Expand

IMFINZI is a prescription medicine used to treat adults with a type of lung cancer called SCLC.

  • IMFINZI may be used alone when your LS-SCLC cannot be removed by surgery and has responded or stabilized after initial treatment with chemotherapy that contains platinum, given at the same time as radiation therapy...

What is the most important information I should know about IMFINZI® (durvalumab)?

IMFINZI is a medicine that may treat certain cancers by work...

IMFINZI is a medicine that may treat certain cancers by working with your immune system. IMFINZI can cause your immune system to...

Read full Important Safety Information