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What is IMFINZI + IMJUDO with chemotherapy?

IMFINZI + IMJUDO with platinum-based chemotherapy is a combination treatment for Stage 4 NSCLC

IMFINZI + IMJUDO are immunotherapies that work with your body’s immune system to help treat Stage 4 NSCLC when used in combination with chemotherapy. They are used together because they work in different ways to attack certain cancer cells. Chemotherapy is a key part of the treatment that attacks rapidly growing cells, such as cancer cells.

IMFINZI + IMJUDO with chemotherapy may also affect healthy cells.

How was IMFINZI + IMJUDO with chemotherapy studied?

A clinical trial compared 2 groups of adults starting a first-line treatment for Stage 4 NSCLC:

Group of People Received IMFINZI and IMJUDO with Platinum-Based Chemotherapy

338 people

received IMFINZI + IMJUDO with platinum-based chemotherapy

Group of People Received Platinum-Based Chemotherapy Alone

337 people

received platinum-based chemotherapy alone

A main goal of the study was to measure how long people in the study lived (called overall survival). Another goal was to measure the length of time people survived without their cancer growing or spreading (called progression-free survival).

IMFINZI + IMJUDO with chemotherapy helped adults with Stage 4 NSCLC live longer compared with chemotherapy alone

Median Overall Survival*

14 Months of Taking IMFINZI and IMJUDO with Chemotherapy
14.0 MONTHS

taking IMFINZI + IMJUDO with chemotherapy

VS

11.7 Months Taking Chemotherapy Alone
11.7 MONTHS

taking chemotherapy
alone

*Median overall survival is the length of time that half the people are living. Median is the middle number in a group of numbers arranged from lowest to highest. IMFINZI + IMJUDO with chemotherapy may not work for everyone. Individual results may vary.

At 2 years†

0%

of people taking
IMFINZI + IMJUDO

0%

of people who received
IMFINZI + IMJUDO with chemotherapy were still living

0%

of people taking
sorafenib

0%

of people who received
chemotherapy alone were still living

†Based on the limits of the analysis, results are descriptive, and your experience may differ.

IMFINZI + IMJUDO with chemotherapy helped people live longer without their cancer growing or spreading compared with chemotherapy alone

Median progression-free survival‡

6.2

months taking
IMFINZI + IMJUDO with
chemotherapy

4.8

months taking
chemotherapy alone

‡Median progression-free survival is the length of time that half of the people lived before their cancer started growing or spreading. IMFINZI + IMJUDO with chemotherapy may not work for everyone. Individual results may vary.

Lower Chance of Cancer Growing or Spreading for People Taking IMFINZI and IMJUDO with Chemotherapy
28%

In the clinical trial, people taking IMFINZI + IMJUDO with chemotherapy had a 28% lower chance of their cancer growing or spreading compared to people taking chemotherapy alone.

What to know before starting IMFINZI + IMJUDO with chemotherapy
Learn about side effects

Important Safety Information

What is the most important information I should know about IMFINZI® (durvalumab) and IMJUDO® (tremelimumab-actl)?

IMFINZI and IMJUDO are medicines that may treat certain cancers by working with your immune system. IMFINZI and IMJUDO can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.

What are IMFINZI and IMJUDO?

IMFINZI and IMJUDO are prescription medicines used to treat adults with a type of lung cancer called NSCLC. IMFINZI may be used in combination with IMJUDO and chemotherapy that contains platinum when your NSCLC has spread to other parts of your body (metastatic) and your tumor does not have an abnormal “EGFR” or “ALK” gene.

It is not known if IMFINZI and IMJUDO are safe and effective in children.

Call or see your healthcare provider right away if you develop any new or worsening signs or symptoms, including:

  • Lung problems: cough, shortness of breath, and chest pain

  • Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; and severe stomach-area (abdomen) pain or tenderness

  • Liver problems: yellowing of your skin or the whites of your eyes, severe nausea or vomiting, pain on the right side of your stomach area (abdomen), dark urine (tea colored), and bleeding or bruising more easily than normal

  • Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; and changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness

  • Kidney problems: decrease in your amount of urine, blood in your urine, swelling of your ankles, and loss of appetite

  • Skin problems: rash; itching; skin blistering or peeling; painful sores or ulcers in mouth or nose, throat, or genital area; fever or flu-like symptoms; and swollen lymph nodes

  • Pancreas problems: pain in your upper stomach area (abdomen), severe nausea or vomiting, and loss of appetite

  • Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with IMFINZI and IMJUDO. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include: Chest pain, irregular heartbeats, shortness of breath or swelling of ankles; confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems; tingling, numbness or weakness of the arms or legs; double vision, blurry vision, sensitivity to light, eye pain, changes in eye sight; persistent or severe muscle pain or weakness, muscle cramps, joint pain, joint stiffness or swelling; and low red blood cells and bruising

  • Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include: chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feel like passing out, fever, and back or neck pain

  • Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with IMFINZI. Your healthcare provider will monitor you for these complications

Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with IMFINZI and IMJUDO. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with IMFINZI and IMJUDO if you have severe side effects

Before you receive IMFINZI and IMJUDO, tell your healthcare provider about all of your medical conditions, including if you:

  • have immune system problems such as Crohn's disease, ulcerative colitis, or lupus
  • have received an organ transplant
  • have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
  • have received radiation treatment to your chest area
  • have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome
  • are pregnant or plan to become pregnant. IMFINZI and IMJUDO can harm your unborn baby

    • Females who are able to become pregnant:

    • Your healthcare provider will give you a pregnancy test before you start treatment with IMFINZI and IMJUDO.
    • You should use an effective method of birth control during your treatment and for 3 months after the last dose of IMFINZI and IMJUDO. Talk to your healthcare provider about birth control methods that you can use during this time.
    • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with IMFINZI and IMJUDO.
  • are breastfeeding or plan to breastfeed. It is not known if IMFINZI and IMJUDO pass into your breast milk. Do not breastfeed during treatment and for 3 months after the last dose of IMFINZI and IMJUDO.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of IMFINZI and IMJUDO?

IMFINZI and IMJUDO can cause serious side effects (see above):

The most common side effects of IMFINZI when used in combination with IMJUDO and platinum-containing chemotherapy in adults with metastatic non-small cell lung cancer (mNSCLC) include nausea, feeling tired or weak, muscle or bone pain, decreased appetite, rash, and diarrhea.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of IMFINZI and IMJUDO. Ask your healthcare provider or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects related to AstraZeneca products. If you prefer to report these to the FDA, either visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

Call your doctor for medical advice about side effects. You may report side effects related to AstraZeneca products. If you prefer to report these to the FDA, either visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

What are IMFINZI and IMJUDO?

IMFINZI and IMJUDO are prescription medicines used to treat adults with a type of lung cancer called NSCLC. IMFINZI may be used in combination with IMJUDO and chemotherapy that contains platinum when your NSCLC has spread to other parts of your body (metastatic) and your tumor does not have an abnormal “EGFR” or “ALK” gene.

It is not known if IMFINZI and IMJUDO are safe and effective in children.

Please see Full Prescribing Information including Medication Guide for IMFINZI and IMJUDO.

What are IMFINZI and IMJUDO?

Important Safety Information

What is the most important information I should know about IMFINZI® (durvalumab) and IMJUDO® (tremelimumab-actl)?

IMFINZI and IMJUDO are medicines that may treat certain cancers by working with your immune system. IMFINZI and IMJUDO can...

IMFINZI and IMJUDO are medicines that may treat...

Read full Important Safety Information

Important Safety Information

What are IMFINZI and IMJUDO?
Minimize Expand

IMFINZI and IMJUDO are prescription medicines used to treat adults with a type of lung cancer called NSCLC. IMFINZI may be used in combination with IMJUDO and chemotherapy that ...

What is the most important information I should know about IMFINZI® (durvalumab) and IMJUDO® (tremelimumab-actl)?

IMFINZI and IMJUDO are medicines that may treat certain cancers by...

IMFINZI and IMJUDO are medicines that may treat certain cancers by working with your immune system. IMFINZI and IMJUDO can...

Read full Important Safety Information