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Key terms to know

It’s normal to have questions about medical terms. This glossary can help you better understand words you might hear from your doctor or see on this website.

ALBI grade (albumin-bilirubin grade)

A grade based on 2 blood tests (albumin and bilirubin) that helps doctors understand liver health

Albumin

A protein made by the liver that helps carry important substances in the blood. Low levels can be a sign of liver problems

Bilirubin

A substance that forms when red blood cells break down. If there’s too much in the blood, it may mean the liver isn’t working well

Biopsy

A procedure where a small sample of tissue is removed from the body and looked at under a microscope to check for cancer or other diseases

Child-Pugh score

A way doctors check how well the liver is working. It uses lab tests and symptoms to give the liver's health a grade (A, B, or C)

Cirrhosis

Severe scarring of the liver that happens over time from liver disease or damage

Computed tomography (CT) scan

An imaging test that takes detailed pictures of the inside of the body using X-rays and a computer

Hepatitis B and hepatitis C

Viral infections that can cause inflammation and damage in the liver. Over time, they may lead to cirrhosis or liver cancer if not treated

Hepatologist

A doctor who specializes in diseases of the liver, gallbladder, bile ducts, and pancreas

Immunotherapy

A type of treatment that works with the immune system to find and attack hidden cancer cells. Immunotherapy may also affect healthy cells

Infusion therapy

A type of medicine given through a needle or a catheter, most likely into a vein

International normalized ratio (INR)

A blood test that shows how well your blood clots. It helps doctors understand how your liver is working

Interventional radiologist

A doctor who uses imaging tools like X-rays or CT scans to guide small instruments inside the body to diagnose or treat diseases without major surgery

Liver cancer

Cancer that starts in the liver. uHCC is a type of liver cancer called unresectable hepatocellular carcinoma

Medical oncologist

A doctor who specializes in treating cancer with medicines like chemotherapy, targeted therapy, or immunotherapy

Metabolic conditions

Health problems that affect how the body uses energy, such as Type 2 diabetes and metabolic dysfunction-associated steatohepatitis (MASH)

Metabolic dysfunction-associated steatotic liver disease (MASLD)

A condition where fat builds up in the liver that isn't due to drinking alcohol. Formerly known as non-alcoholic fatty liver disease (NAFLD)

Metabolic dysfunction-associated steatohepatitis (MASH)

The more severe form of MASLD, or fatty liver disease, where fat builds up in the liver, causing inflammation and scarring. Formerly known as non-alcoholic steatohepatitis (NASH)

Multidisciplinary team (MDT)

A group of healthcare professionals from different specialties who work together to plan and manage a patient’s care

Obesity

Having too much body fat, which can increase the risk of liver diseases like MASLD, MASH, and liver cancer

Oncologist

A doctor who specializes in treating cancer

Oncology nurse

A nurse who cares for people with cancer, helps give treatments, manages side effects, and provides support and education

Programmed death-ligand 1 (PD-L1)

A protein that disguises cancer cells from your immune system

Primary liver cancer

Cancer that starts in the liver rather than spreading there from another part of the body

Radiation oncologist

A doctor who treats cancer using radiation therapy to kill or shrink cancer cells

Type 2 diabetes (T2D)

A condition where the body doesn’t use insulin properly, leading to high blood sugar levels

Ultrasound

An imaging test that uses sound waves to look at organs inside the body

Unresectable

A tumor that cannot be removed with surgery because of its size, location, or because it has spread to other parts of the body

Unresectable hepatocellular carcinoma (uHCC)

The most common type of primary liver cancer. It starts in the main cells of the liver called hepatocytes. Hepatocellular carcinoma is considered unresectable when the tumor can’t be removed with surgery. This may be due to several reasons. The cancer may be too large to be removed without leaving behind enough of the liver to still work. The cancer cannot be removed in order to keep a safe amount of blood flow coming in and out of the liver. The cancer has spread to other parts of the body

Important Safety Information

What is the most important information I should know about IMFINZI® (durvalumab) and IMJUDO® (tremelimumab-actl)?

IMFINZI and IMJUDO are medicines that may treat certain cancers by working with your immune system. IMFINZI and IMJUDO can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.

What are IMFINZI and IMJUDO?

IMFINZI is a prescription medicine used in combination with IMJUDO to treat adults with a type of liver cancer that cannot be removed by surgery (unresectable hepatocellular carcinoma or uHCC).

It is not known if IMFINZI and IMJUDO are safe and effective in children.

Call or see your healthcare provider right away if you develop any new or worsening signs or symptoms, including:

  • Lung Problems Icon

    Lung problems: cough, shortness of breath, and chest pain

  • Intestinal Problems Icon

    Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; and severe stomach-area (abdomen) pain or tenderness

  • uHCC Liver Problem Icon

    Liver problems: yellowing of your skin or the whites of your eyes, severe nausea or vomiting, pain on the right side of your stomach area (abdomen), dark urine (tea colored), and bleeding or bruising more easily than normal

  • uHCC Hormone Gland Problems Icon

    Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; and changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness

  • uHCC Kidney Problems Icon

    Kidney problems: decrease in your amount of urine, blood in your urine, swelling of your ankles, and loss of appetite

  • uHCC Skin Problems Icon

    Skin problems: rash; itching; skin blistering or peeling; painful sores or ulcers in mouth or nose, throat, or genital area; fever or flu-like symptoms; and swollen lymph nodes

  • uHCC Pancreas Problems Icon

    Pancreas problems: pain in your upper stomach area (abdomen), severe nausea or vomiting, and loss of appetite

  • uHCC Patient Icon

    Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with IMFINZI and IMJUDO. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include: Chest pain, irregular heartbeats, shortness of breath or swelling of ankles; confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems; tingling or numbness of the arms or legs; double vision, blurry vision, sensitivity to light, eye pain, changes in eye sight; persistent or severe muscle pain or weakness, muscle cramps, joint pain, joint stiffness or swelling; and low red blood cells and bruising

  • uHCC Patient Icon

    Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include: chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feel like passing out, fever, and back or neck pain

  • Immune System Rejecting a Transplanted Organ Icon

    Rejection of a transplanted organ or tissue. Your healthcare provider should tell you what signs and symptoms you should report and monitor you depending on the type of organ or tissue transplant that you have had

  • uHCC Complications Icon

    Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with IMFINZI. Your healthcare provider will monitor you for these complications

Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with IMFINZI and IMJUDO. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with IMFINZI and IMJUDO if you have severe side effects

Before you receive IMFINZI and IMJUDO, tell your healthcare provider about all of your medical conditions, including if you:

  • have immune system problems such as Crohn's disease, ulcerative colitis, or lupus
  • have received an organ or tissue transplant, including corneal transplant
  • have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
  • have received radiation treatment to your chest area
  • have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome
  • are pregnant or plan to become pregnant. IMFINZI and IMJUDO can harm your unborn baby

    • Females who are able to become pregnant:

    • Your healthcare provider will give you a pregnancy test before you start treatment with IMFINZI and IMJUDO.
    • You should use an effective method of birth control during your treatment and for 3 months after the last dose of IMFINZI and IMJUDO. Talk to your healthcare provider about birth control methods that you can use during this time.
    • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with IMFINZI and IMJUDO.
  • are breastfeeding or plan to breastfeed. It is not known if IMFINZI and IMJUDO pass into your breast milk. Do not breastfeed during treatment and for 3 months after the last dose of IMFINZI and IMJUDO.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of IMFINZI and IMJUDO?

IMFINZI and IMJUDO can cause serious side effects (see above).

The most common side effects of IMFINZI and IMJUDO in adults with unresectable hepatocellular carcinoma (uHCC) include rash, diarrhea, feeling tired, itchiness, muscle or bone pain, and stomach (abdominal) pain.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of IMFINZI and IMJUDO. Ask your healthcare provider or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects related to AstraZeneca productsReport side effects related to AstraZeneca products. If you prefer to report these to the FDA, either visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

Call your doctor for medical advice about side effects. You may report side effects related to AstraZeneca productsReport side effects related to AstraZeneca products. If you prefer to report these to the FDA, either visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

What are IMFINZI and IMJUDO?

IMFINZI is a prescription medicine used in combination with IMJUDO to treat adults with a type of liver cancer that cannot be removed by surgery (unresectable hepatocellular carcinoma or uHCC).

It is not known if IMFINZI and IMJUDO are safe and effective in children.

Please see Full Prescribing Information including Medication Guide for IMFINZI and IMJUDO.

What are IMFINZI and IMJUDO?

Important Safety Information

What is the most important information I should know about IMFINZI® (durvalumab) and IMJUDO® (tremelimumab-actl)?

IMFINZI and IMJUDO are medicines that may treat certain cancers by working with your immune system. IMFINZI and IMJUDO can...

IMFINZI is a medicine that may treat...

Read full Important Safety Information

Important Safety Information

What are IMFINZI and IMJUDO?

Minimize Expand

IMFINZI is a prescription medicine used in combination with IMJUDO to treat adults with a type of liver cancer that cannot be removed by surgery (unresectable hepatocellular carcinoma or uHCC).

What is the most important information I should know about IMFINZI® (durvalumab) and IMJUDO® (tremelimumab-actl)?

IMFINZI is a medicine that may treat certain cancers by work...

IMFINZI and IMJUDO are medicines that...

Read full Important Safety Information