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~80 %

~80 %

An estimated 41,000 people in the US were diagnosed with liver cancer in 2024.

About 80% of these cases are uHCC, making it the most common type of liver cancer in adults. More than half of people aren’t diagnosed until the cancer has spread beyond the liver.

Because symptoms often don’t appear until the advanced stages, a diagnosis like uHCC can come as a shock. It’s natural to feel overwhelmed, but it’s important to know you are not alone.

Hepatocellular carcinoma is considered unresectable when the tumor can’t be removed with surgery. This may be due to its size, location near major blood vessels, or because the cancer has spread to other areas of the body.

Liver

What can increase the risk of liver cancer?

Some health conditions and lifestyle habits may raise the chances of developing liver cancer:

  • Cirrhosis, or scarring of the liver, which may happen after years of liver damage
  • Hepatitis B or C, both of which may cause long-term liver inflammation
  • Type 2 diabetes (T2D), which may be associated with changes in liver health
  • Obesity, smoking, or heavy alcohol use, which may increase the chance of developing liver problems

Fat buildup in the liver, or metabolic dysfunction-associated steatotic liver disease (MASLD). The more severe form of this condition is called metabolic dysfunction-associated steatohepatitis (MASH), which may cause potential damage to liver cells

Liver

Other common chronic conditions in people living with liver cancer

Other health conditions may occur alongside liver cancer. These are called comorbidities. They may affect how well the liver works. Some common comorbidities include:

  • Hypertension (high blood pressure)
  • Coronary heart disease
  • Cerebral infarction (damage to your brain after a stroke)

These conditions are important for your doctor to monitor and manage as part of your care
during treatment.

uHCC Search Icon

How to screen for liver cancer

Blood tests can help tell your doctor how your liver is working. But it's important to tell your doctor if you notice any symptoms such as excessive weight loss, abdominal (stomach) pain, loss of appetite, or nausea. They will usually do imaging tests like ultrasounds, CT scans, or MRIs for a detailed look, then do blood tests for more information. In some cases, a liver biopsy is needed to confirm the diagnosis and learn more about the cancer.

Doctors will continue monitoring your liver health with these different tests after diagnosis and throughout treatment. Ask your doctor about these tests. Your doctor may explain the results and how they help shape your treatment plan.

Who’s on your care team?

uHCC (a type of liver cancer) is a condition that’s often treated by a multidisciplinary team, or MDT. This team brings together different specialists who work closely to create your treatment plan.

Healthcare professionals on your MDT might include:

  • Medical Oncologist Doctor Icon
    Medical oncologist

    a doctor who treats cancer with medicines like chemotherapy, targeted therapy, or immunotherapy

  • Hepatologist Doctor Icon
    Hepatologist

    a doctor who is an expert in liver health. They will monitor your liver health during treatment

  • Interventional Radiologist Doctor Icon
    Interventional radiologist

    a doctor who uses special tools and imaging to help treat cancer

  • Radiation Oncologist Doctor Icon
    Radiation oncologist

    a doctor who uses radiation to help treat cancer

  • Oncology Nurse Icon
    Oncology nurse

    a nurse who helps explain cancer treatments, provides support, and coordinates care

Other experts might be involved too, like dietitians or social workers.

It’s normal to have questions along the way. Being open with your care team can help lead to clearer answers, more support, and care that truly fits you.

Liver cancer treatment advancements may bring hope

Being diagnosed with liver cancer can feel sudden and difficult to process. No matter how your condition started, there are still reasons to be hopeful as doctors study new ways to understand and treat types of liver cancer like uHCC.

uHCC Care Team Icon

Learn more about how each person on your care team can help support you from diagnosis through treatment

Understand who makes up your care team

Questions to ask your doctor or care team:

  • Question IconWhat does a uHCC diagnosis mean for me?
  • Question IconHow will cancer affect my day-to-day health?
  • Question IconWhat are my treatment options?
See more questions to
guide your next appointment
Learn about the results of IMFINZI + IMJUDO for uHCC
See the clinical trial results

Important Safety Information

What is the most important information I should know about IMFINZI® (durvalumab) and IMJUDO® (tremelimumab-actl)?

IMFINZI and IMJUDO are medicines that may treat certain cancers by working with your immune system. IMFINZI and IMJUDO can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.

What are IMFINZI and IMJUDO?

IMFINZI is a prescription medicine used in combination with IMJUDO to treat adults with a type of liver cancer that cannot be removed by surgery (unresectable hepatocellular carcinoma or uHCC).

It is not known if IMFINZI and IMJUDO are safe and effective in children.

Call or see your healthcare provider right away if you develop any new or worsening signs or symptoms, including:

  • Lung Problems Icon

    Lung problems: cough, shortness of breath, and chest pain

  • Intestinal Problems Icon

    Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; and severe stomach-area (abdomen) pain or tenderness

  • uHCC Liver Problem Icon

    Liver problems: yellowing of your skin or the whites of your eyes, severe nausea or vomiting, pain on the right side of your stomach area (abdomen), dark urine (tea colored), and bleeding or bruising more easily than normal

  • uHCC Hormone Gland Problems Icon

    Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; and changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness

  • uHCC Kidney Problems Icon

    Kidney problems: decrease in your amount of urine, blood in your urine, swelling of your ankles, and loss of appetite

  • uHCC Skin Problems Icon

    Skin problems: rash; itching; skin blistering or peeling; painful sores or ulcers in mouth or nose, throat, or genital area; fever or flu-like symptoms; and swollen lymph nodes

  • uHCC Pancreas Problems Icon

    Pancreas problems: pain in your upper stomach area (abdomen), severe nausea or vomiting, and loss of appetite

  • uHCC Patient Icon

    Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with IMFINZI and IMJUDO. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include: Chest pain, irregular heartbeats, shortness of breath or swelling of ankles; confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems; tingling or numbness of the arms or legs; double vision, blurry vision, sensitivity to light, eye pain, changes in eye sight; persistent or severe muscle pain or weakness, muscle cramps, joint pain, joint stiffness or swelling; and low red blood cells and bruising

  • uHCC Patient Icon

    Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include: chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feel like passing out, fever, and back or neck pain

  • Immune System Rejecting a Transplanted Organ Icon

    Rejection of a transplanted organ or tissue. Your healthcare provider should tell you what signs and symptoms you should report and monitor you depending on the type of organ or tissue transplant that you have had

  • uHCC Complications Icon

    Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with IMFINZI. Your healthcare provider will monitor you for these complications

Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with IMFINZI and IMJUDO. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with IMFINZI and IMJUDO if you have severe side effects

Before you receive IMFINZI and IMJUDO, tell your healthcare provider about all of your medical conditions, including if you:

  • have immune system problems such as Crohn's disease, ulcerative colitis, or lupus
  • have received an organ or tissue transplant, including corneal transplant
  • have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
  • have received radiation treatment to your chest area
  • have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome
  • are pregnant or plan to become pregnant. IMFINZI and IMJUDO can harm your unborn baby

    • Females who are able to become pregnant:

    • Your healthcare provider will give you a pregnancy test before you start treatment with IMFINZI and IMJUDO.
    • You should use an effective method of birth control during your treatment and for 3 months after the last dose of IMFINZI and IMJUDO. Talk to your healthcare provider about birth control methods that you can use during this time.
    • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with IMFINZI and IMJUDO.
  • are breastfeeding or plan to breastfeed. It is not known if IMFINZI and IMJUDO pass into your breast milk. Do not breastfeed during treatment and for 3 months after the last dose of IMFINZI and IMJUDO.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of IMFINZI and IMJUDO?

IMFINZI and IMJUDO can cause serious side effects (see above).

The most common side effects of IMFINZI and IMJUDO in adults with unresectable hepatocellular carcinoma (uHCC) include rash, diarrhea, feeling tired, itchiness, muscle or bone pain, and stomach (abdominal) pain.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of IMFINZI and IMJUDO. Ask your healthcare provider or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects related to AstraZeneca productsReport side effects related to AstraZeneca products. If you prefer to report these to the FDA, either visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

Call your doctor for medical advice about side effects. You may report side effects related to AstraZeneca productsReport side effects related to AstraZeneca products. If you prefer to report these to the FDA, either visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

What are IMFINZI and IMJUDO?

IMFINZI is a prescription medicine used in combination with IMJUDO to treat adults with a type of liver cancer that cannot be removed by surgery (unresectable hepatocellular carcinoma or uHCC).

It is not known if IMFINZI and IMJUDO are safe and effective in children.

Please see Full Prescribing Information including Medication Guide for IMFINZI and IMJUDO.

What are IMFINZI and IMJUDO?

Important Safety Information

What is the most important information I should know about IMFINZI® (durvalumab) and IMJUDO® (tremelimumab-actl)?

IMFINZI and IMJUDO are medicines that may treat certain cancers by working with your immune system. IMFINZI and IMJUDO can...

IMFINZI is a medicine that may treat...

Read full Important Safety Information

Important Safety Information

What are IMFINZI and IMJUDO?

Minimize Expand

IMFINZI is a prescription medicine used in combination with IMJUDO to treat adults with a type of liver cancer that cannot be removed by surgery (unresectable hepatocellular carcinoma or uHCC).

What is the most important information I should know about IMFINZI® (durvalumab) and IMJUDO® (tremelimumab-actl)?

IMFINZI is a medicine that may treat certain cancers by work...

IMFINZI and IMJUDO are medicines that...

Read full Important Safety Information